Brigham and Women's Hospital

Inflammatory disorders

New therapeutic strategy to prevent gastrointestinal disease

Food allergies, celiac disease, inflammatory bowel disease (IBD), diarrhea and other gastrointestinal diseases have something in common: all have been linked to epithelial barrier loss. The gut epithelial barrier—that critical ...

Diseases, Conditions, Syndromes

New therapeutic targets for kidney fibrosis emerge

Chronic kidney disease is a global health concern, affecting about 10 percent of the world's population—and increasing in prevalence. A final, common pathway in chronic kidney disease is fibrosis. Just as fibrosis—or ...

Oncology & Cancer

The hitchhiker's guide to defeating glioblastoma

In cancer therapeutics research, microRNAs—tiny strings of nucleotides that get churned out inside cells—have been a source of both excitement and disappointment. While preclinical studies have found that microRNAs play ...

Oncology & Cancer

New drug targets for BRCA-driven cancer uncovered

BRCA1 and BRCA2 ("BReast CAncer genes") are critical tumor suppressor genes—women carrying a mutation in one of these genes have up to an 80 percent risk of developing breast cancer and a 50 percent risk of developing ovarian ...

HIV & AIDS

Cellphone technology developed to detect HIV

The management of human immunodeficiency virus 1 (HIV), an autoimmune disorder that cripples the immune system by attacking healthy cells, remains a major global health challenge in developing countries that lack infrastructure ...

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