The goal of cancer treatment is to match the right drug to the right target in the right patient. But before such "personalized" drugs can be developed, more knowledge is needed about specific genomic alterations in cancers ...
Mar 28, 2012
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Researchers have developed a new technology that flexibly scales up CRISPR-based molecular diagnostics, using microfluidics chips that can run thousands of tests simultaneously. A single chip's capacity ranges from detecting ...
Apr 30, 2020
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Epilepsy is one of the most widespread neurological disorders, but relatively little is known about the genes involved in the more common types. By examining all the genes of over 17,000 people, an international research ...
Jul 24, 2019
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Researchers at the Broad Institute of MIT and Harvard and Princeton University have developed a CRISPR-based technology that can rapidly differentiate between omicron, delta, and other COVID-19 variants, as well as other ...
Feb 8, 2022
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Cancer drugs called immune checkpoint inhibitors boost the immune system's ability to find and destroy tumor cells, but they don't work for most patients. Researchers at the Broad Institute of MIT and Harvard, Massachusetts ...
May 6, 2021
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Atrial fibrillation (Afib), a heart condition that causes a rapid, irregular heartbeat that increases a person's risk of stroke and heart failure, is fairly common among older adults. However, its early onset form is relatively ...
Dec 11, 2018
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The immune system keeps T cells under control by regulating precisely when they can respond to a pathogen. For instance, helper T cells only turn "on" if other immune cells, such as antigen-presenting cells (APCs) present ...
Oct 23, 2018
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Researchers have generated a long list of genetic mutations linked to cancer, but sorting out which ones really drive tumors to grow uncontrollably and which ones don't has been a challenge. A new mathematical model developed ...
Sep 17, 2019
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In defining the cellular context of diffuse midline gliomas, researchers find the cells fueling their growth and suggest a potential approach to treating them: forcing their cells to be more mature.
Apr 20, 2018
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Most of the DNA alterations that are tied to disease do not alter protein-coding genes, but rather the "switches" that control them. Characterizing these switches is one of many goals of the ENCODE project – a sweeping, ...
Sep 5, 2012
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