Cancer researchers today announced they have developed a way of sidelining one of the most dangerous "bad actors" in leukemia. Their approach depends on throwing a molecular wrench into the gears of an important machine that ...
Jan 8, 2018
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Although genomic testing can be useful for clinical diagnosis, most patients have no obvious genomic changes despite a strong indication of a genetic condition. In a paper published in the March issue of Cold Spring Harbor ...
Mar 1, 2016
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A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character - from aggressive ...
Dec 22, 2015
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One way of discovering a gene's function is to switch it off and observe how the loss of its activity affects an organism. If a gene is essential for survival, however, then switching it off permanently will kill the organism ...
Apr 14, 2011
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Cancer researchers at Cold Spring Harbor Laboratory (CSHL) have carried out the first comprehensive study of the changes seen in the DNA of a patient with mast cell leukemia (MCL), an extremely aggressive subtype of acute ...
Dec 16, 2011
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Chandelier cells are neurons that use their unique shape to act like master circuit breakers in the brain's cerebral cortex. These cells have dozens, often hundreds, of branching axonal projections – output channels from ...
Jan 16, 2014
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Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it. Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc and former graduate student ...
Jan 11, 2022
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An international group of researchers led by Cold Spring Harbor Laboratory (CSHL) Assistant Professor Gholson Lyon has identified a new genetic mutation associated with intellectual disability, developmental delay, autism ...
Apr 12, 2018
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Evolution is thought to proceed through the gradual accumulation of independent mutations in each new generation. In a study published online today in Genome Research, researchers analyzing hominid genomes have discovered ...
Apr 7, 2016
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Pancreatitis is an inflammation of the pancreas that accounts for 275,000 hospitalizations in the United States annually. Patients who suffer from hereditary pancreatitis have a 40 to 50 percent lifetime risk of developing ...
Jun 20, 2019
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