Columbia University School of Engineering and Applied Science

Biomedical technology

Plug-and-play organ-on-a-chip can be customized to the patient

Engineered tissues have become a critical component for modeling diseases and testing the efficacy and safety of drugs in a human context. A major challenge for researchers has been how to model body functions and systemic ...

Biomedical technology

New technology could make biopsies a thing of the past

A Columbia Engineering team has developed a technology that could replace conventional biopsies and histology with real-time imaging within the living body. Described in a new paper published today in Nature Biomedical Engineering, ...

Neuroscience

Discovering how the brain works through computation

Accelerating progress in neuroscience is helping us understand the big picture—how animals behave and which brain areas are involved in bringing about these behaviors—and also the small picture—how molecules, neurons, ...

Oncology & Cancer

Designer probiotic treatment for cancer immunotherapy

Researchers at Columbia Engineering have engineered probiotics to safely deliver immunotherapies within tumors. These include nanobodies against two proven therapeutic targets—PD-L1 and CTLA-4. The drugs are continuously ...

Oncology & Cancer

Bacteria engineered as Trojan horse for cancer immunotherapy

The emerging field of synthetic biology—designing new biological components and systems—is revolutionizing medicine. Through the genetic programming of living cells, researchers are creating engineered systems that intelligently ...

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