Hokkaido University

Immunology

Repeated interferon stimulation creates innate immune memory

Mammalian cells seem to be able to memorize anti-viral stimulation at the level of DNA-packaging molecules, enabling faster and greater activation of anti-viral genes in subsequent stimulations, according to a study conducted ...

Oncology & Cancer

New micro-platform reveals cancer cells' natural behavior

A new cell culture platform allows researchers to observe never-before-seen behaviors of live cancer cells under the microscope, leading to explanations of long-known cancer characteristics.

Oncology & Cancer

Mitochondria come together to kill cancer cells

Targeting a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy.

Cardiology

The molecules that energize babies' hearts

A metabolic process that provides heart muscle with energy fails to mature in newborns with thickened heart walls, according to a Japan–Canada research team.

Diseases, Conditions, Syndromes

Key molecule for flu infection identified

After decades of research, a research team has discovered the key receptor molecule that enhances the infection of the influenza A virus, providing a novel target for anti-flu drug development.

Oncology & Cancer

Obesity inhibits key cancer defense mechanism

Obesity is a known risk factor for certain types of cancer, including colon, pancreatic and breast cancer. Studies have shown its role in promoting tumor growth and malignant progression. But its role in cancer initiation ...

Immunology

Unraveling the immunopathogenesis of Johne's disease

Researchers of Hokkaido University, the National Agriculture and Food Research Organization (NARO), and Tohoku University demonstrated that a physiologically active substance called prostaglandin E2 (PGE2) impairs the immune ...

Genetics

The gene causing new brain disorder

Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.

Diseases, Conditions, Syndromes

Ebola virus exploits host enzyme for efficient entry to target cells

Researchers have identified a key process that enables the deadly Ebola virus to infect host cells, providing a novel target for developing antiviral drugs. The Ebola virus incorporates a cellular enzyme into its virus particles, ...

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