Howard Hughes Medical Institute

HIV & AIDS

A macaque model of HIV infection

Researchers have taken a major step toward developing a better animal model of human AIDS. Such a model could greatly improve researchers' ability to evaluate potential strategies for preventing and treating the disease.

Oncology & Cancer

New generation mTOR inhibitors aim to combat drug-resistant tumors

Howard Hughes Medical Institute scientists have designed a potential cancer therapy that uses a unique strategy to block mTOR, a molecule that helps drive the growth of many tumors. In animal experiments, the drug reduces ...

Neuroscience

Fast and slow—learning how the brain controls movement

What if you couldn't move faster even when you wanted to? Researchers thought that the part of the brain that determines how fast we perform voluntary movements, such as walking across a room or playing a melody on the piano, ...

Genetics

Clock gene may connect mood and sleep

If you pull an all-nighter or stay up late to binge watch Game of Thrones, you will probably be grumpy the next day. But if you don't get enough sleep for weeks or months on end, you may develop depression or other lasting ...

Genetics

Breakable genes may promote disease and brain cell diversity

Howard Hughes Medical Institute (HHMI) researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage. The fragility of those genes could explain why they are often mutated or deleted in cancers ...

Neuroscience

New studies examine cellular diversity in the hippocampus

Researchers at the Howard Hughes Medical Institute's Janelia Research Campus have uncovered unexpected diversity within a single, canonical cell type of the mammalian brain. Their analysis of cells called CA1 pyramidal neurons ...

Neuroscience

Adaptive optics helps reveal what the eyes tell the brain

When photoreceptors in the retina of the eye detect light, they relay the information toward the brain's primary visual cortex for image processing. Scientists at the Howard Hughes Medical Institute's Janelia Research Campus ...

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