Radiotherapy works by damaging the DNA of cancer cells. It's an effective strategy overall, but many cancers have subsets of cells that are able to survive initial radiotherapeutic regimens by using DNA damage repair mechanisms. ...
May 28, 2021
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Cancer research using experimental models—everything from cancer cells in a dish to patient tumors transplanted in mice—has been extremely useful for learning more about the disease and how we might treat it. For some ...
Feb 10, 2020
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The Glioma Longitudinal Analysis (GLASS) Consortium characterized diffuse glioma cells both before and after therapy to characterize how they change and why this form of malignant brain cancer is so difficult to treat. The ...
Nov 20, 2019
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Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or "spelling mistakes" in the DNA sequence, but even more variation comes from structural variants, which ...
Apr 16, 2019
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A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
Sep 20, 2018
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The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer's disease (AD), has released eight new models carrying genetic mutations found in patients.
Jul 23, 2018
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Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center (UConn Health) and The Jackson Laboratory (JAX) have identified 40 subtypes ...
Jul 18, 2018
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Humans inherited the capacity to hear sounds thanks to structures that evolved millions of years ago. Sensory "hair cells" in the inner ear have the amazing ability to convert sound waves into electrical signals and transmit ...
Dec 11, 2017
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In vaccination, a certain subpopulation of dendritic cells is vital to triggering the body's adaptive immune system, report researchers at The Jackson Laboratory (JAX), Yale University and Astra-Zeneca.
Dec 1, 2017
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A research team has revealed the intrinsic gene expression patterns of glioblastoma (GBM) tumors, insights that could drive more effective treatments for GBM, the most common and deadly malignant primary brain tumors in adults.
Jul 10, 2017
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