Journal of the National Cancer Institute

Oncology & Cancer

Probing the mechanism of ADAM28-mediated cancer metastasis

ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives ...

Oncology & Cancer

Improving cancer communication to patients

Oncologists and their patients are increasingly challenged with making difficult decisions about screening, prevention and treatment. Unfortunately, most patients are neither armed with adequate knowledge nor the means of ...

Oncology & Cancer

Margin threshold for women with ductal carcinoma in situ

Negative surgical margins should be attained for ductal carcinoma in situ (DCIS) patients after breast-conserving surgery (BCS) regardless of radiotherapy, and surgeons should attempt to reach wide negative margins in their ...

Oncology & Cancer

Higher than normal levels of Vitamin B12 may indicate cancer risk

Vitamin B12 (cobalamin [Cbl]) is essential for maintaining healthy bodily function but higher than normal levels (reference range 200-600 pmol/L) may indicate that a patient is at risk of developing certain cancers, according ...

Oncology & Cancer

Plant-based compound slows breast cancer in a mouse model

The natural plant compound phenethyl isothiocyanate (PEITC) hinders the development of mammary tumors in a mouse model with similarities to human breast cancer progression, according to a study published August 2 in the Journal ...

page 5 from 25