A long, long time ago, the BCG vaccine was approved for use against tuberculosis (TB), and it's still given to infants today. For generations, the vaccine has saved lives and prevented untold suffering. And yet TB still kills ...
Dec 13, 2021
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A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent ...
May 27, 2019
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A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus—beyond the key sites on the virus's spike protein. ...
Jan 27, 2021
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As scientists around the world develop life-saving COVID-19 vaccines and therapies, many are still wondering exactly why the disease proves deadly in some people and mild in others.
Oct 6, 2020
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For a glimpse into the future of SARS-CoV-2 immunity, scientists at La Jolla Institute for Immunology (LJI) are investigating how the immune system builds its defenses against common cold coronaviruses (CCCs).
Jul 22, 2022
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T cells play important roles in helping to fight infections and cancers—and they can also drive autoimmune diseases. Now researchers at La Jolla Institute for Immunology (LJI) have discovered new genes in CD4+ "helper" ...
Feb 25, 2022
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Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation in the arteries.
May 20, 2022
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In addition to the four major bases in the DNA alphabet—A, C, G and T—there is also a minor "fifth" base, 5-methylcytosine (5mC), which plays a disproportionately important role in deciding whether genes and other DNA ...
Jul 29, 2019
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New research shows how genetic variations linked to severe cases of COVID-19 affect our immune cells.
Nov 19, 2021
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Every year, more than 68,000 people end up with a clinical case of Japanese encephalitis. One in four of these patients will die. The mosquito-borne virus, which is most common in Southeast Asia, also causes severe neurological ...
Jun 5, 2020
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