Scientists from St. Jude Children's Research Hospital have identified a genetic variant associated with substantially increased risk of heart disease in survivors of childhood cancer treated with the chemotherapy doxorubicin. ...
Jun 14, 2022
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Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment resistance. Scientists at St. Jude Children's Research ...
May 9, 2022
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Scientists from St. Jude Children's Research Hospital have identified variants in two genes that are associated with accelerated aging in childhood cancer survivors. Their research looked at the difference between their ...
Mar 22, 2022
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Scientists at St. Jude Children's Research Hospital and the Cancer Research Center in Spain blocked development of acute lymphoblastic leukemia in mice with a genetic mutation that increases the risk of childhood cancer.
Feb 7, 2022
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Scientists at St. Jude Children's Research Hospital are studying the impact of genetic ancestry on childhood acute lymphoblastic leukemia (ALL), the most common type of pediatric cancer. The team found that ancestry itself ...
Jan 27, 2022
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Scientists at St. Jude Children's Research Hospital have a new understanding of how a group of well-known fusion oncoproteins causes leukemia. The findings show the importance of liquid-liquid phase separation (LLPS), a process ...
Dec 13, 2021
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St. Jude Children's Research Hospital is testing a treatment for cancer called a chimeric antigen receptor (CAR) T cell. T cells are a kind of immune cell. They help fight infections and diseases such as cancer. Scientists ...
Nov 30, 2021
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St. Jude Children's Research Hospital scientists looking for drugs to improve survival of children with high-risk neuroblastoma found a promising candidate in CX-5461. Then researchers identified safety concerns with the ...
Nov 9, 2021
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St. Jude Children's Research Hospital scientists have identified a new strategy that takes advantage of an unexpected regulator of inflammatory cell death to shrink tumors in mice. The study appeared today in Cell Reports.
Oct 19, 2021
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Research from a large international effort shows that 20% of children with cancer who are infected with SARS-CoV-2 develop severe infections. In studies of children overall, only 1-6% have reported severe infections. The ...
Aug 26, 2021
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