Oncology & Cancer

Pushing T cells down 'memory lane' may improve cancer therapy

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T-cell therapy for treatment of solid tumors. The results were published today in ...

Diseases, Conditions, Syndromes

Dynamics of adaptive immunity in tuberculosis uncovered

Unlike other infectious diseases that affect the lungs, the immune response to fight tuberculosis (TB) infections develops at least twice as slowly. Until recently, the dynamic interplay between bacteria and the host's immune ...

Oncology & Cancer

Researchers identify key factors impacting adaptive cancer therapy

Most cancer treatments are based on using the maximum tolerated dose of a drug to kill as many cancer cells as possible. While this approach has led to patients achieving good responses to therapy, most patients develop drug ...

Immunology

Discovery of an innate immunological memory in the intestine

The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa. Using an intestinal infection model, scientists from ...

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