Alzheimer's disease & dementia

Researchers uncover novel amyloidosis

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein that induces amyloidosis in rats. This new amyloid protein is known to be the lipopolysaccharide ...

Cardiology

Three-drug tx ups survival in light-chain amyloidosis

(HealthDay)—For patients with heart failure due to light-chain amyloidosis (AL), three-drug therapy with bortezomib, dexamethasone, and an alkylating agent (BDex+AA) is associated with improved survival, according to a ...

Diseases, Conditions, Syndromes

Serum free light chain level increase precedes amyloidosis

(HealthDay)—Increased serum free light chains (FLCs) precede the presentation of immunoglobulin light chain amyloidosis (AL amyloidosis), according to a study published online July 14 in the Journal of Clinical Oncology.

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Amyloidosis

In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it takes on a particular aggregated insoluble form, similar to the beta-pleated sheet. Symptoms vary widely depending upon the site of amyloid deposition, i.e. where in the body these "bad proteins" are found in significant numbers. Amyloidosis may be inherited or acquired.

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