An orally bioavailable androgen receptor PROTAC, developed using a protein degradation technology, was effective in lowering tumor burden in mice bearing human castration-resistant prostate cancer, according to data presented ...
Apr 5, 2017
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Research led by University of Birmingham scientists in collaboration with Northwestern University in Chicago, US, has provided fresh insight into the role of male hormone in supporting and disrupting the production of eggs ...
Apr 3, 2017
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A new analysis of patients who have undergone treatment for prostate cancer shows a connection between androgen deprivation therapy (ADT)—a testosterone-lowering therapy and a common treatment for the disease—and dementia, ...
Mar 30, 2017
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Scientists have discovered that the male androgen hormone is an important element in the ovarian development of female chicken embryos, more so than in the development of male testes.
Mar 23, 2017
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A newly discovered genetic mutation that is found in a subtype of prostate cancer is integral to the disease's development and growth, according to research from Weill Cornell Medicine scientists. Their findings could pave ...
Mar 14, 2017
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Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.
Mar 10, 2017
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Advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient ...
Mar 9, 2017
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Men who used testosterone replacement therapy to treat symptoms of androgen deficiency had a 33 percent lower risk of cardiovascular events such as heart attacks and stroke compared to those who did not receive any hormone ...
Feb 21, 2017
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A research team has studied for the first time the 3-D structure of the homodimeric androgen receptor ligand-binding domain, a structure that eluded researchers for years. This new structure of the nuclear receptor explains ...
Feb 7, 2017
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A large-scale, population based study led by Dr. Laurent Azoulay, Senior Investigator with the Lady Davis Institute at the Jewish General Hospital, has concluded that the use of androgen deprivation therapy (ADT) to treat ...
Jan 26, 2017
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