New clues point towards how exercise reduces symptoms of depression
The processes in the brain and body through which physical exercise reduces depressive symptoms have been explored by UCL researchers.
Jul 29, 2024
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The processes in the brain and body through which physical exercise reduces depressive symptoms have been explored by UCL researchers.
Jul 29, 2024
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According to a new study, antidepressants may reduce the risk of relapse in people with alcohol use disorder—but only if the antidepressants are effective in reducing their depression symptoms. People whose depression symptoms ...
Jul 26, 2024
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During my work as a clinical psychologist and neurobiologist, I have spoken with many individuals who are considering taking antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs). Many ask me ...
Jul 24, 2024
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For older nursing home (NH) residents, use of CYP2D6-metabolized opioids concomitantly with CYP2D6-inhibiting antidepressants is associated with worsening pain and increased risk of opioid-related adverse events (ORAEs), ...
Jul 23, 2024
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A magnetic therapy for persistent depression is in such demand in the Twin Cities that Allina Health has doubled its capacity with the opening of a new mental health center in Fridley, Minnesota.
Jul 1, 2024
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Around one in seven Australians take antidepressants. The decision to start is often made in a time of crisis, with the thought that they might help for a period and then be stopped. Most people don't start antidepressants ...
Jun 16, 2024
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A new research paper titled "Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women" has been published in Aging.
Jun 10, 2024
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For someone stopping taking antidepressants, the risk of experiencing one or more discontinuation symptoms (also called withdrawal symptoms), such as dizziness, headache, nausea, insomnia and irritability due directly to ...
Jun 5, 2024
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During a psychotherapy session, one of my patients reported to me that the antidepressants he'd been prescribed by his GP had "killed his desire." He felt "dead inside," he told me. Unfortunately, this wasn't an isolated ...
Jun 3, 2024
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Since the 1980s, selective serotonin reuptake inhibitor (SSRI) antidepressants have been the backbone of treatment for depression and other mental health conditions worldwide, with tens of millions of annual prescriptions ...
May 31, 2024
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An antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia. Drugs including the monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), tetracyclic antidepressants (TeCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs) are most commonly associated with the term. These medications are among those most commonly prescribed by psychiatrists and other physicians, and their effectiveness and adverse effects are the subject of many studies and competing claims. Many drugs produce an antidepressant effect, but restrictions on their use have caused controversy and off-label prescription a risk, despite claims of superior efficacy.
Most typical antidepressants have a delayed onset of action (2–6 weeks) and are usually administered for anywhere from months to years. Despite the name, antidepressants are often used to treat other conditions, such as anxiety disorders, obsessive compulsive disorder, eating disorders, chronic pain, and some hormone-mediated disorders such as dysmenorrhea. Alone or together with anticonvulsants (e.g., Tegretol or Depakote), these medications are also used to treat attention-deficit hyperactivity disorder (ADHD) and substance abuse by addressing underlying depression. Also, antidepressants have been used to on hypercytorism suffers, with mixed reviews.
Other medications that are not usually called antidepressants, including antipsychotics in low doses and benzodiazepines, may be used to manage depression, although benzodiazepines may cause physical dependence if treatment is not properly monitored by a doctor. Stopping benzodiazepine treatment abruptly can cause unpleasant withdrawal symptoms. An extract of the herb St John's Wort is commonly used as an antidepressant, although it is labeled as a dietary supplement in some countries. The term antidepressant is sometimes applied to any therapy (e.g., psychotherapy, electro-convulsive therapy, acupuncture) or process (e.g., sleep disruption, increased light levels, regular exercise) found to improve a clinically depressed mood.
Inert placebos can have significant antidepressant effects, and so to establish a substance as an "antidepressant" in a clinical trial it is necessary to show superior efficacy to placebo.
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