Oncology & Cancer

New immunotherapy for leukemia discovered

Researchers at Karolinska Institutet, University of Oslo and Oslo University Hospital have developed a new kind of immunotherapy for leukemia. The results of a study published in Nature Biotechnology show that the therapy ...

Immunology

Discovering a new B cell that tempers autoimmunity

Researchers at the National Eye Institute (NEI) have identified, isolated, and characterized a unique population of B cells that tamps down the immune system, reducing chronic inflammation. Infusions of purified IL-27 regulatory ...

Medical research

Potential therapeutic pathway to clear chronic viral infections

Chronic infectious diseases have a devastating effect on global health. When someone is suffering from a chronic viral infection such as HIV or hepatitis C, their B cells get altered resulting in low-quality antibodies that ...

Oncology & Cancer

Receptor structure reveals new targets for cancer treatment

A molecule known as anaplastic lymphoma kinase (ALK) is a driver of several cancers, including pediatric neuroblastoma, B-cell lymphomas, and myofibroblast tumors. But for years much about this molecule—its role in the ...

Medical research

Unsung gene is key to how antibodies develop: study

Researchers at the University of Toronto have discovered that an overlooked gene plays a major role in the development of antibodies, which help the immune system recognize and fight viruses including SARS-CoV-2, bacteria ...

Oncology & Cancer

GABA released by B-cells blunts the immune response to tumors

A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted ...

Diseases, Conditions, Syndromes

SARS-CoV-2 disrupts timing of immune response

Once an infection is under control, the body normally uses a biochemical messenger known as TGFβ to downgrade its immune response. In severe COVID-19, however, this messenger is released at the very beginning of the infection, ...

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