A massive research effort over more than a quarter century has tried to make personalized blood stem cells for use in treating leukemias, among many other uses. One way researchers have gone about this is to sample a patient's ...
Jan 16, 2020
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A stem cell transplant—also called a bone marrow transplant—is a common treatment for blood cancers, such as acute myeloid leukemia (AML). Such treatment can cure blood cancers but also can lead to life-threatening complications, ...
Jan 15, 2020
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A pilot gene therapy treatment for sickle cell disease, restoring patients' ability to make fetal hemoglobin, has produced good results in the first three patients to receive it. Investigators at Boston Children's Hospital ...
Jan 10, 2020
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When a person's immune system is impaired by a genetic disease, a bone-marrow transplant can be a powerful therapeutic tool, but with a major downside: during the first few months the recipient's defenses against viruses ...
Jan 2, 2020
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The reconstitution of the blood system in humans holds great therapeutic potential to treat many disorders, like blood cancers, sickle-cell anemia and others. Successful reconstitution requires the transplantation and engraftment ...
Dec 31, 2019
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A group of researchers at Osaka University revealed that endothelial cell-selective adhesion molecule (ESAM), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important ...
Dec 27, 2019
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Four months after treating them, Yasuhiro Shiga, MD, Ph.D., checked on his rats. Walking into the lab, he carried minimal expectations. Treating spinal cord injuries with stem cells had been tried by many people, many times ...
Dec 17, 2019
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Thanks to the 'cut and paste' gene editing technique CRISPR, scientists are homing in on a cure for sickle cell disease—a genetic blood disorder—while other research is looking at how to expand the potential of CRISPR-based ...
Dec 16, 2019
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When the immune system detects a foreign pathogen, a cascade of chemical signals call white blood cells to the scene. Neutrophils are the most common and abundant type of these cells and while they start accumulating at the ...
Dec 13, 2019
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In the summer, a mother in Nashville with a seemingly incurable genetic disorder finally found an end to her suffering—by editing her genome.
Dec 5, 2019
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