Oncology & Cancer
New targeted drugs could treat drug-resistant skin cancer
Clinical trials to test the new drugs in patients should begin as early as 2015.
Dec 11, 2014
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News tagged with braf
Oncology & Cancer
Next-gen melanoma drug, TAK-733, excels in lab tests
A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental ...
Nov 11, 2014
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Oncology & Cancer
New data on combination treatments for melanoma
Combination therapy with both BRAF inhibitor vemurafenib and MEK inhibitor cobimetinib achieves greater progression-free survival and response rates than vemurafenib plus placebo in BRAF-mutation positive melanoma, according ...
Sep 29, 2014
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Oncology & Cancer
New insight into drug resistance in metastatic melanoma
(Medical Xpress)—A study by scientists in Manchester has shown how melanoma drugs can cause the cancer to progress once a patient has stopped responding to treatment.
Jun 3, 2014
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Oncology & Cancer
Study shows tale of two prognoses in pediatric brain tumor, pilocytic astrocytoma
Pilocytic astrocytoma (PA) is a primarily pediatric brain tumor caused mainly by mutations in the BRAF gene. In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene ...
Jun 2, 2014
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Oncology & Cancer
Patients with metastatic colon cancer respond to new combination therapy
In an aggressive disease known for poor response rates, researchers from The University of Texas MD Anderson Cancer Center found patients with advanced colorectal cancer responded well to a combination therapy of the drugs ...
May 31, 2014
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Oncology & Cancer
Non-uniform genetic mutations identified in lung cancers could lead to targeted treatment
The research, published in the journal Oncotarget, explored tumour heterogeneity – where different cells have different appearances or their own DNA signatures within the same cancer. Such differences could make it difficult ...
Apr 23, 2014
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Oncology & Cancer
Blocking autophagy with malaria drug may help overcome resistance to melanoma BRAF drugs
Half of melanoma patients with the BRAF mutation have a positive response to treatment with BRAF inhibitors, but nearly all of those patients develop resistance to the drugs and experience disease progression.
Feb 24, 2014
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Oncology & Cancer
New molecular targets identified in some hard-to-treat melanomas provide potential treatment option
Stand Up To Cancer (SU2C), the charitable initiative supporting ground-breaking research aimed at getting new cancer treatments to patients in an accelerated timeframe, announces that Jeffrey A. Sosman, M.D., a Stand Up To ...
Dec 31, 2013
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Oncology & Cancer
Stage III/IV melanoma patients at risk for new primaries
(HealthDay)—Patients with stage III or IV melanoma who have not received treatment with BRAF inhibitors remain at risk for developing new primary melanomas (NPMs), although the incidence rates are lower than those observed ...
Dec 10, 2013
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