Neuroscience

Tissue model reveals role of blood-brain barrier in Alzheimer's

Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer's patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier—the normally tight border that ...

Medical research

Alzheimer's disease protein links plaques to cell death in mice

A new protein involved in Alzheimer's disease (AD) has been identified by researchers at the RIKEN Center for Brain Science (CBS). CAPON may facilitate the connection between the two most well-known AD culprits, amyloid plaques ...

Alzheimer's disease & dementia

Artificial intelligence tool vastly scales up Alzheimer's research

Researchers at UC Davis and UC San Francisco have found a way to teach a computer to precisely detect one of the hallmarks of Alzheimer's disease in human brain tissue, delivering a proof of concept for a machine-learning ...

Neuroscience

Why visual stimulation may work against Alzheimer's

Several years ago, MIT neuroscientists showed that they could dramatically reduce the amyloid plaques seen Alzheimer's disease in mice simply by exposing the animals to light flickering at a specific frequency.

Alzheimer's disease & dementia

Alzheimer's disease is a 'double-prion disorder,' study shows

Two proteins central to the pathology of Alzheimer's disease act as prions—misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape—according to new ...

Neuroscience

Do microglia hold the key to stop Alzheimer's disease?

A Leuven research team led by Prof. Bart De Strooper (VIB-KU Leuven, UK DRI) studied how specialized brain cells called microglia respond to the accumulation of toxic proteins in the brain, a feature typical of Alzheimer's. ...

Alzheimer's disease & dementia

A new culprit of cognitive decline in Alzheimer's disease

It has long been known that patients with Alzheimer's disease have abnormalities in the vast network of blood vessels in the brain. Some of these alterations may also contribute to age-related cognitive decline in people ...

Alzheimer's disease & dementia

Study points to new method to deliver drugs to the brain

Researchers at the University of Rochester Medical Center (URMC) have discovered a potentially new approach to deliver therapeutics more effectively to the brain. The research could have implications for the treatment of ...

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