Women with harmful mutations in the BRCA gene, which put them at higher risk of developing breast and ovarian cancer, tend to undergo menopause significantly sooner than other women, allowing them an even briefer reproductive ...
Jan 29, 2013
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Scientists led by Drs. Mona Gauthier and Tak Mak at The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre have solved a key piece in the puzzle of how BRCA1 gene mutations specifically ...
Jul 15, 2013
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Our DNA, which stores our genetic information, is constantly exposed to damage. If not properly repaired, DNA damage can lead to cell death. This, in turn, can lead to tissue exhaustion and ageing, or induce mutations resulting ...
Jan 3, 2013
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Patients with breast cancer who had a BRCA1 mutation had significantly worse overall and recurrence-free survival rates compared with patients without BRCA mutations, but no evidence for a difference in survival was found ...
Apr 9, 2013
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(HealthDay)—Women who have specific mutations in genes known as BRCA are at increased risk for breast and ovarian cancers. Now, an influential expert panel reaffirms that certain women should be screened for the genes.
Feb 19, 2019
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Increasingly, the words "genetics" and "genome" are making their way into news stories about health and medicine. Doctors talk about scientific research—how there may be links between gene mutations in your DNA and an increased ...
Jan 28, 2019
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(HealthDay)—Oral contraceptive use is associated with a reduced risk for ovarian cancer for BRCA mutation carriers, according to a study published in the July issue of the American Journal of Obstetrics & Gynecology.
Jul 7, 2021
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In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced ...
May 15, 2013
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(HealthDay)—Use of tamoxifen and age at treatment for breast cancer predict chemotherapy-induced amenorrhea among premenopausal women, according to research published online Aug. 26 in the Journal of Clinical Oncology.
Aug 28, 2013
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(HealthDay)—Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.
Feb 20, 2013
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