Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed
Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.
Jan 27, 2012
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Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.
Jan 27, 2012
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(PhysOrg.com) -- Localized hyperthermia has been used occasionally with cancer drugs for some time, but until now, the reason it helps has been a mystery. In a report in the Proceedings of the National Academy of Sciences, ...
The association between menstrual cycle activity and breast and ovarian cancer risk may have an unexpected intermediary - odors.
Oct 21, 2015
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(HealthDay) -- Girls who receive radiation to the chest to treat childhood cancer, even those getting lower doses, have a high risk of developing breast cancer at a young age, according to a new study.
Jun 4, 2012
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Scientists from Cardiff University have uncovered a protein which drives aggressive breast cancer and could be targeted for developing new and improved therapies.
Dec 27, 2018
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Inherited mutations in the BRCA1 gene can significantly increase a person's risk of breast and ovarian cancer—but not every mutation in the gene is harmful. To better equip patients and their doctors to understand and manage ...
Jun 3, 2022
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The PARP inhibitor, olaparib, that has shown promise in women with an inherited mutation in their BRCA1 or BRCA2 gene (accounting for about 5-10% of breast and ovarian cancer cases), has, for the first time, been shown to ...
Aug 21, 2011
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BRCA1 (BReast CAncer Gene 1), a key gene that becomes faulty in some instances, leading to breast and ovarian cancer, plays an important role in the body's DNA repair mechanisms. BRCA1, once mutated, can cause cancer to develop. ...
Nov 17, 2022
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The same genes that greatly increase the risk of breast cancer in U.S. white women, including women of Ashkenazi Jewish descent, also greatly increase breast cancer risk among African American women. These genes include the ...
May 19, 2020
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As medical science links certain genetic mutations with a greater variety of cancers, the names for these risk syndromes are falling out of step.
Jul 4, 2019
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BRCA1 ( /ˈbrækə/; breast cancer 1, early onset) is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990. The gene was later cloned in 1994 by scientists at Myriad Genetics.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
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