Most cancer drugs that target specific genetic mutations are designed for adult cancers rather than those in children, partly because pediatric cancers have fewer mutations. To look for more ways to target childhood cancers, ...
Mar 23, 2021
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Cancer mutations often incapacitate critically important genes, forcing tumors to depend heavily on other genes for survival. Such genetic dependencies are attractive targets for new cancer therapies.
Dec 16, 2020
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A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types. Scientists at ...
Dec 20, 2019
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Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth. The resulting ...
Apr 11, 2019
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In one of the largest studies of its kind, researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer's survival. The team, ...
Apr 10, 2019
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