While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted ...
Mar 1, 2022
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Gene therapy trials for sickle cell disease have been showing great promise, even offering hope of a cure. But in early 2021, the trials ground to a halt after reports of blood malignancies in two people in a trial sponsored ...
Feb 15, 2022
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In 2010, doctors treated Doug Olson's leukemia with an experimental gene therapy that transformed some of his blood cells into cancer killers. More than a decade later, there's no sign of cancer in his body.
Feb 6, 2022
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City of Hope today announced study results of a Phase 2 clinical trial showing monotherapy with sotorasib resulted in anti-tumor activity and a favorable benefit-risk profile among heavily pretreated patients with advanced ...
Dec 15, 2021
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Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor. However, the treatment isn't very effective because cancer cells can activate antioxidant ...
Dec 8, 2021
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A comprehensive study—conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups—has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor ...
Nov 11, 2021
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Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by reinvigorating a subset ...
Oct 29, 2021
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A new study from Linköping University has shown that the tumor-inhibiting gene TET2 is silenced in a large fraction of cases of acute lymphoblastic leukemia (ALL) in children. The scientists show that the gene can be reactivated ...
Aug 25, 2021
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Lung cancer is the leading cause of cancer death among men and women in the United States, regardless of ethnicity. Non-small cell lung cancer is the most common form of the disease, accounting for 84% of all diagnoses. One ...
Aug 3, 2021
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Breast cancer is the leading cause of cancer death in women around the world, responsible for 1,700 deaths every day. Although the vast majority of breast cancers are treatable, the most aggressive subtype—triple negative ...
Jun 7, 2021
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