Oncology & Cancer

Cancer DNA blood tests validated by international research team

An international team today reports the findings of an independent assessment of five commercially-available assays for tumor DNA sequencing—a fast, cheap and less invasive method to diagnose and monitor cancer.

Oncology & Cancer

Researchers identify genes behind uterine leiomyosarcoma

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS). Furthermore, using fully sequenced patient-derived xenografts, the team has preclinically validated new ...

Oncology & Cancer

Case study of rare nervous system tumor reveals hypermutation

While deadly, gliosarcomas are a rare central nervous system tumor often overshadowed in research by more common tumors. These sarcomas can occur either in the brain or the spine (the latter is much less common).

Oncology & Cancer

Pediatric cancers have unique genetic vulnerabilities

Most cancer drugs that target specific genetic mutations are designed for adult cancers rather than those in children, partly because pediatric cancers have fewer mutations. To look for more ways to target childhood cancers, ...

Oncology & Cancer

A leap forward in research on CAR T cell therapy

In cancer immunotherapy, cells in the patient's own immune system are activated to attack cancer cells. CAR T cell therapy has been one of the most significant recent advances in immunotherapies targeted at cancer.

Oncology & Cancer

Cancer immunotherapy approach targets common genetic alteration

Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response against cells that are ...

Oncology & Cancer

Predicting success in therapy with individualized cancer models

In the EU alone, 78,800 men died of prostate cancer last year. While tumors discovered at an early stage can often be completely removed by surgery and radiation therapy, the prospects of successful treatment are reduced ...

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