Medical research

Studying the function of liver cancer genes in mini-organs

Researchers from the Hubrecht Institute and Radboud University have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Using this ...

Cancer

Mutations synergize in pediatric brain cancer

A new Northwestern Medicine study finds that a combination of two mutations cause a form of pediatric brain tumors to become more deadly, according to findings published in Nature Communications.

Cancer

Conquering cancer's infamous KRAS mutation

KRAS is one of the most challenging targets in cancer. Despite its discovery more than 60 years, researchers still struggle to inhibit its mutated form—earning its reputation as "undruggable." Yet, the hunt for an Achilles' ...

Cancer

Form drives function in cancer proliferation

A new study finds that the protein responsible for the crawling movements of cells also drives the ability of cancer cells to grow when under stress.

Cancer

At molecular level, cancer mutations echo Darwin's observations

There are more than 100 mutations of the protein behind the deadly brain cancer, glioblastoma, however an international research team has discovered something these mutations have in common. The new understanding could lead ...

Cancer

Gene defends against onset of acute leukaemia

Institute scientists have revealed that a gene called PHF6 plays a powerful role in protecting against blood cancer. The study showed how a breakdown in the gene's function could accelerate the development of T cell acute ...

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