Oncology & Cancer

Structural insights reveal how SPOP protein contributes to cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood. Scientists at St. ...

Medical research

Stopping a rare childhood cancer in its tracks

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered a new drug target for Ewing sarcoma, a rare kind of cancer usually diagnosed in children and young adults. Their experiments show that the cells causing this ...

Medical research

New molecular blocker halts breast cancer metastasis, says study

An estimated ninety percent of deaths from breast cancer are due to complications resulting from metastasis, a process in which cancer cells break away from where they first formed, travel through the blood or lymph circulatory ...

Medical research

Protein movement reveals brain tumor's weak spot

Proteins do not have a single shape, but are more like dynamic robots. But—how do they actually move? And what does this tell us about their function? Laura Orellana describes the movement of proteins using computer simulations—and ...

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