When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn't ...
Apr 22, 2021
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A team of researchers at Stanford University has found a way to reinvigorate exhausted engineered CAR-T cells by giving them a time-out period to recover. In their paper published in the journal Science, the group describes ...
A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the ...
Apr 2, 2021
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In cancer immunotherapy, cells in the patient's own immune system are activated to attack cancer cells. CAR T cell therapy has been one of the most significant recent advances in immunotherapies targeted at cancer.
Mar 18, 2021
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The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for estrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with ...
Mar 8, 2021
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A new study finds that California's commuters are likely inhaling chemicals at levels that increase the risk for cancer and birth defects.
Feb 15, 2021
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Chimeric Antigen Receptor T-cell therapy—CAR T—has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical ...
Jan 22, 2021
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Scientists at Dana-Farber Cancer Institute and Mass General Cancer Center have created molecular ON-OFF switches to regulate the activity of CAR T cells, a potent form of cell-based immunotherapy that has had dramatic success ...
Jan 6, 2021
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Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's blood and subjected to genetic ...
Dec 14, 2020
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Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies ...
Nov 26, 2020
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