NIBIB-funded researchers have developed a 3-D-printed scaffold coated in aggrecan, a native cartilage component, to improve the regeneration of cartilage tissue in joints. The scaffold was combined with a common microfracture ...
Jan 15, 2019
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A network of carbohydrate binding proteins—so-called galectins—plays an important role in the degeneration of cartilage in osteoarthritis. A research group at the MedUni Vienna was able to demonstrate this correlation, ...
Dec 19, 2018
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Osteoarthritis, a disease that causes severe joint pain, affects more than 20 million people in the United States. Some drug treatments can help alleviate the pain, but there are no treatments that can reverse or slow the ...
Nov 28, 2018
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A combinatorial gene therapy approach- one designed to inhibit inflammation and one targeting protection against cartilage degeneration—was shown to preserve articular cartilage better than each approach alone in animal ...
Nov 13, 2018
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Researchers of Valencia's Polytechnic University (UPV), the University of Notre Dame (USA) and the Technological University of Auckland (New Zealand), along with multinational company Zimmer, have developed a new material ...
Oct 31, 2018
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During cartilage development, chondrocytes secrete the extracellular matrix (ECM) and embed within the same environment. During progressive joint disease, such as osteoarthritis (OA), dysregulation of the process can lead ...
Knee joint injuries are typically related to sports, such as football, rugby or ice hockey, but people often do not know that such injuries may lead to joint inflammation and post-traumatic osteoarthritis. In advanced post-traumatic ...
Oct 25, 2018
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Osteoarthritis is a disabling disease characterised by joint pain and restricted mobility, affecting especially the elderly. The disease generally progresses slowly, even over decades. Post-traumatic osteoarthritis, however, ...
Oct 18, 2018
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Researchers from the Faculty of Chemical Technology, Kaunas University of Technology (KTU), Lithuania are developing an artificial bone that can be used to treat osteoarthritis. The bi-functional composite imitates the complex ...
Sep 26, 2018
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Highly specialized cartilage is characteristically avascular and non-neural in composition with low cell numbers in an aliphatic environment. Despite its apparent simplicity, bioengineering regenerative hyaline cartilage ...
Cartilage is a type of dense connective tissue existing within many joints. It is composed of specialized cells called chondrocytes that produce a large amount of extracellular matrix composed of collagen fibers, abundant ground substance rich in proteoglycan, and elastin fibers. Cartilage is classified in three types, elastic cartilage, hyaline cartilage and fibrocartilage, which differ in the relative amounts of these three main components.
Cartilage is found in many areas in the body, including the articular surface of the bones, the rib cage, the ear, the nose, the bronchial tubes and the intervertebral discs. Its mechanical properties are intermediate between bone and dense connective tissue like tendon.
Unlike other connective tissues, cartilage does not contain blood vessels. The chondrocytes are fed by diffusion, helped by the pumping action generated by compression of the articular cartilage or flexion of the elastic cartilage. Thus, compared to other connective tissues, cartilage grows and repairs more slowly.
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