Immunology

Holes in the immune system left unrepaired despite drug therapy

If they don't receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system. But a very small percentage of patients—0.3%—spontaneously control the virus themselves, without ...

HIV & AIDS

Newly discovered immune cells at the frontline of HIV infection

Researchers at The Westmead Institute for Medical Research have discovered brand new immune cells that are at the frontline of HIV infection. Known as CD11c+ dendritic cells, these new cells are more susceptible to HIV infection ...

Medications

Major HIV drug requires vigilance, study says

A study lead by researchers at the Institute of HIV Research, Medical Faculty of UDE and University Hospital Essen reports a potential toxicity of integrase inhibitors. Integrase inhibitors (INSTI) are a preferred drug for ...

Diseases, Conditions, Syndromes

A new culprit for multiple sclerosis relapses

A molecule that helps blood clot may also play a role in multiple sclerosis relapses, researchers report in the May 6 issue of PNAS. The new research may help answer the mystery of why remissions happen, as well as find early ...

HIV & AIDS

In rare cases, immune system fails despite HIV suppression

Antiretroviral therapy (ART) is usually very effective at suppressing HIV in the body, allowing a person's immune system to recover by preventing the virus from destroying CD4+ T cells. Scientists have now identified a rare, ...

HIV & AIDS

Gut microbiome may contribute to HIV transmission in high-risk men

Gut microbes from high HIV-risk men who have sex with men drive immune activation in mice and HIV infection in cells, according to a study published April 4 in the open-access journal PLOS Pathogens by Brent Palmer and Catherine ...

Immunology

New proof that narcolepsy is an autoimmune disease

Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease. This knowledge may lead ...

Oncology & Cancer

Using anti-cancer immunotherapy to fight HIV

Researchers at the University of Montreal Hospital Research Centre (CRCHUM) have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy. In a study published ...

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CD4

CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.

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