Oncology & Cancer

The novel mechanisms for inflammation and cancer induced by HTLV-1

A research group from Kumamoto University, Japan, has clarified the mechanism by which human T-cell leukemia virus type 1 (HTLV-1) causes inflammation and oncogenesis. The action of the viral gene HTLV-1 bZIP factor (HBZ) ...

HIV & AIDS

Researchers discover how HIV hides from treatment

Even after successful antiretroviral therapy, HIV can hide dormant in a tiny number of immune system cells for decades and re-emerge to threaten the life of its host. Now Yale University researchers have discovered a molecular ...

Diseases, Conditions, Syndromes

What underlies differing disease severity in COVID-19?

Researchers have reported a significant and positive relationship between the amount of virus present in a throat swab sample and the severity of COVID disease. The higher the relative viral load in the sample, the greater ...

Oncology & Cancer

A new therapeutic target turns the immune system against lymphoma

Non-Hodgkin's lymphoma (NHL) is a group of cancers that originate in the lymph nodes and affect white blood cells of the immune system called B cells. In NHL, B cells grow out of control and create tumors in the lymph nodes, ...

HIV & AIDS

What people living with HIV need to know about COVID-19

Nearly half of people in the U.S. diagnosed with HIV, the virus that causes AIDS, are over 50, according to the Centers for Disease Control and Prevention (CDC). HIV damages the body's immune system, and interferes with the ...

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CD4

CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.

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