The RB1 tumor suppressor gene protein antagonizes uncontrolled growth of cancer by suppressing cell cycle progression but its function is repressed in most cancers. CDK4/6 represses this function by phosphorylating RB1. In ...
Sep 2, 2021
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Clear cell renal cell carcinoma (ccRCC) cells can be destroyed and kept from multiplying by inhibiting the HDL cholesterol receptor SCARB1, according to research from the Perelman School of Medicine at the University of Pennsylvania. ...
Aug 11, 2021
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Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma, according to results from a phase II clinical trial published in ...
Aug 6, 2021
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Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, ...
Aug 5, 2021
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Keratinocyte carcinomas, including basal cell and squamous cell carcinomas, are the most common types of cancer in the United States, with approximately 5.4 million cases diagnosed each year. Despite their low mortality rate, ...
Aug 3, 2021
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A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration ...
Jul 23, 2021
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Immunotherapy has revolutionized the treatment of inoperable, metastasised skin cancer. More than 50% of patients are still alive more than five years after treatment, whereas, 10 years ago, this figure was not even 5%. The ...
Jul 20, 2021
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DEAR MAYO CLINIC: I have a significant number of moles. While most do not bother me, I have at least one that bleeds from time to time. Should I see my doctor for a mole that bleeds?
Jul 8, 2021
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Today, as they did 100 years ago, doctors diagnose cancer by taking tissue samples from patients, which they usually fix in formalin for microscopic examination. In the past 20 years, genetic methods have also been established ...
Jun 17, 2021
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DEAR MAYO CLINIC: About a year ago, I had a heart transplant and I've been doing well since. At a recent follow-up visit, my transplant doctor recommended a skin check with a dermatologist. What's the connection?
Jun 11, 2021
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