Oncology & Cancer

Taming overactive molecular signaling in renal cell cancer

In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling ...

Oncology & Cancer

CDK4: A master regulator of the cell cycle and its role in cancer

The mammalian cell cycle is divided into four phases, Gap 1 (G1), Synthesis (S), Gap 2 (G2) and Mitosis (M), whose order and timing are critical for accurate transmission of genetic information. Consequently, a number of ...

Oncology & Cancer

DDX41: A key nuclear player in maintaining genomic stability

The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To this end, researchers from ...

Diabetes

Research unlocks the circuitry of diabetes

Research led by Pamela-Itkin-Ansari, Ph.D., and Randal Kaufman Ph.D., has mapped out a network of biochemical interactions that help special cells in the pancreas called islet cells create insulin, shedding light on the origins ...

Obstetrics & gynaecology

Vaginal immune system may hint at prime vaccine timing

Levels of key immune-signaling molecules in the vagina "undergo clear and consistent" fluctuations during the menstrual cycle, a University of Washington Medicine-led team reports in a study published today in the journal ...

page 4 from 22