Immunology

Testing their strength: CAR T-cells combat muscle inflammation

Universitätsklinikum Erlangen is the first in the world to use CAR T-cells to successfully treat a patient suffering from a severe case of muscle inflammation (myositis). The disease is triggered by a malfunction in the ...

Medications

Receptor location matters for psychedelic drug effects

Location, location, location is the key for psychedelic drugs that could treat mental illness by rapidly rebuilding connections between nerve cells. In a paper published in Science, researchers at the University of California, ...

Diseases, Conditions, Syndromes

New study identifies T cells involved in the autoimmune disease AAV

Many patients with the autoimmune disease ANCA-associated vasculitis (AAV) suffer a high risk of disease relapse despite treatment. Karolinska Institutet researchers have now identified T cells that contribute to the destruction ...

Diseases, Conditions, Syndromes

Sensory cells taste cerebrospinal fluid to fight brain infections

Sensory neurons pick up information from our senses and relay it to the rest of the nervous system. But this is not their only mission. In a new study published in the journal Current Biology, Claire Wyart at the Paris Brain ...

Oncology & Cancer

CAR-T cell cancer immunotherapy gets personal

New adoptive T cell therapies—in which T cells, the immune system's natural hunters patrolling the body for foreign adversaries, are retrieved from cancer-riddled patients, super-charged and amplified outside the body, ...

Medical research

Study suggests possible way to 'Smac' cancer

In animals, a process of programmed cell death called apoptosis ensures cells die when they should. An opposing force, governed by inhibitor of apoptosis proteins (IAPs), guards against excessive cell death. Together these ...

Medical research

How hepatitis E viruses enter cells

Although hepatitis E is a common disease, little is known about the life cycle of the virus. Initial findings on how it manages to infect cells are reported by a team from Molecular and Medical Virology at Ruhr University ...

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