A new research paper titled "Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity" has been published in Aging.
Jan 31, 2023
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It's not the fountain of youth, but a fast-emerging class of drugs could bring us closer to achieving the age-old quest for longer life, better health, and greater vitality.
Jun 23, 2021
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In our 2014 Research Strategy we included an intention to facilitate a major shift in early detection and diagnosis research. We made an ambitious commitment to invigorate this field, stimulating research interest, building ...
Jun 21, 2017
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Most cells can divide only a limited number of times and eventually undergo permanent cell cycle arrest, a state known as cellular senescence. Cellular senescence is mediated by activation of specific cellular signaling pathways ...
Aug 4, 2016
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A common feature of cancer and aging is cells' reduced ability to respond to stress-induced damage to DNA or cellular structures. Specifically, changes occur in the protective processes of apoptosis and cellular senescence, ...
Jul 13, 2016
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We all know that too much food combined with too little exercise can add up to poor health and disease. But overeating and inactivity also speed up the aging process, right down to our cells. At the end of a cell's lifespan, ...
Apr 29, 2014
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Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") ...
Jun 6, 2011
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