Medications

Reducing lung inflammation in young kids with cystic fibrosis

In findings published in the journal The Lancet Respiratory Medicine, the COMBAT CF trial found azithromycin—a commonly prescribed broad-spectrum antibiotic—when used as a preventive therapy helped reduce the inflammation ...

Oncology & Cancer

Genetic master controls expose cancers' Achilles' heel

In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...

Alzheimer's disease & dementia

Obesity + aging linked to Alzheimer's markers in the brain

A new study suggests that when a high-fat, high-sugar diet that leads to obesity is paired with normal aging, it may contribute to the development of Alzheimer's disease. In addition, researchers discovered that certain areas ...

Medical research

Elimination of senescent cells improves lung function in mice

Most cells can divide only a limited number of times and eventually undergo permanent cell cycle arrest, a state known as cellular senescence. Cellular senescence is mediated by activation of specific cellular signaling pathways ...

Diseases, Conditions, Syndromes

How the brain's housekeeper malfunctions during bacterial meningitis

Bacterial meningitis is a life-threatening infectious disease of the brain that leaves many survivors with long-lasting neurological impairments. Now, researchers at Karolinska Institutet in Sweden show in a study on rats ...

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