Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle ...
Apr 3, 2023
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You might not think of diabetes when you think of muscle function. But a common diabetes drug that regulates blood sugar can also prevent muscle atrophy and muscular fibrosis—which can help the elderly bounce back faster ...
Jul 25, 2023
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An arrest in cell proliferation, also referred to as cellular senescence, occurs as a natural result of aging and in response to cellular stress. Senescent cells accumulate with age and are associated with many aging phenotypes, ...
Nov 15, 2013
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Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") ...
Jun 6, 2011
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Despite decades of research, Alzheimer's disease remains a debilitating and eventually fatal dementia with no effective treatment options. More than 95 percent of Alzheimer's disease cases have no known origin. Now, scientists ...
Dec 1, 2022
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Pelvic floor disorders (PFDs), which occur when women's pelvic floor muscles are weakened or injured, significantly affect quality of life and require surgery for hundreds of thousands in the U.S. each year. Now a study led ...
Jul 5, 2023
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Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor ...
Apr 18, 2013
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Prof. Liu Guanghui and his colleagues from the Institute of Zoology and the Beijing Institute of Genomics of the Chinese Academy of Sciences have collaborated to find that Apolipoprotein E (APOE) destabilizes heterochromatin ...
Apr 7, 2022
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Senescent cells have a bad-guy reputation when it comes to aging. While cellular senescence - a process whereby cells permanently lose the ability to divide when they are stressed - suppresses cancer by halting the growth ...
Dec 11, 2014
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Although a link has been established between chronic inflammation and neurodegenerative diseases, there have been many open questions regarding how cellular senescence, a process whereby cells that stop dividing under stress ...
Jan 30, 2020
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