Diseases, Conditions, Syndromes

New insight into RASopathy-associated lymphatic defects

The RAS pathway is a cellular signaling pathway that regulates growth and development in humans. RASopathies are a group of diseases characterized by defects in RAS signaling.

Medical research

Study may lead to new strategies against sepsis

Scientists at the Center for Translational Medicine at the Temple University School of Medicine are inching closer to solving a long-standing mystery in sepsis, a complex and often life-threatening condition that affects ...

Medical research

Trapping malaria parasites inside host cell basis for new drugs

One of the most insidious ways that parasitic diseases such as malaria and toxoplasmosis wreak their havoc is by hijacking their host's natural cellular processes, turning self against self. Researchers from the Perelman ...

Oncology & Cancer

Cancer biology: Keeping bad company

The p53 tumor suppressor protein manages DNA repair mechanisms in response to genetic damage and kills off precancerous cells before they multiply. The loss of p53 due to mutation greatly increases risk of tumorigenesis. ...

Medical research

The X factor in liver metabolism

After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway ...

Oncology & Cancer

Cancer cells co-opt immune response to escape destruction

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth.

Medical research

A factor involved in painful joint wear and tear discovered

Inflammatory joint disease (arthritis) is affecting more and more, and especially older, people. In a recent survey by Statistik Austria, 39 per cent of people over the age of 60 stated that they have a form of arthritis. ...

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