Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers have discovered that accumulation of a type of lipid (fat), known as ceramides, plays a crucial role in lipotoxic cardiomyopathy (LCM)—a heart condition ...
Mar 6, 2018
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Understanding how cancer cells are able to metastasize—migrate from the primary tumor to distant sites in the body—and developing therapies to inhibit this process are the focus of many laboratories around the country. ...
Dec 15, 2017
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Many drug-resistant tumors have dysfunctional metabolism of ceramide, a metabolite that promotes cell death.
Sep 21, 2022
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Fluoxetine, a common antidepressant, inhibits the SARS-CoV-2 coronavirus in cell cultures and in preparations from human lung tissue. This was demonstrated by researchers at Julius-Maximilians-Universität (JMU) Würzburg ...
Aug 17, 2022
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A new University of Kentucky College of Medicine study has identified potential targets to develop a therapy that could prevent Alzheimer's disease.
Jun 15, 2022
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Type 2 diabetes and cardiovascular disease are preceded by metabolic alterations. A current study by the DZD and DIfE indicates that specific lipid molecules (ceramides), which are produced when the body metabolizes fats, ...
Feb 22, 2022
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Dr. Shui Guanghou's team from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has recently demonstrated that Ceramide synthases 2 (CerS2) plays a critical role in maintaining hepatic ...
Feb 15, 2022
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Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation ...
Jan 27, 2022
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In a new study using mice, Johns Hopkins Medicine researchers have found a better way than natural healing to repair damaged insulation surrounding nerve cells. Normally, the natural healing process adds bumps to the surface ...
Oct 27, 2020
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Novel blood-based biomarkers for dementia could identify disease at an early preclinical stage, serve as surrogate outcomes for clinical trials of investigational therapies and even identify future potential therapeutic targets. ...
Feb 14, 2020
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