A multinational team of researchers led by Columbia University has discovered that tumors can repurpose a single cellular protein to hide themselves from the immune system in two distinct ways. Drugs targeting that protein ...
Feb 2, 2024
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Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system ...
Nov 23, 2022
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Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system's T cells to attack tumor cells. Their introduction a decade ago marked a major advance in cancer therapy, but only 10% to 30% ...
Nov 15, 2022
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Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed and optimized a minimally invasive method for more targeted, efficient, and sustained delivery of immunotherapeutic treatments for cancer. ...
Aug 2, 2022
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Immune checkpoint inhibitors have revolutionized cancer care. The therapy works by preventing tumors from shutting down the immune response, which in turn allows T cells to kill cancer cells. Established checkpoint inhibitors ...
Jun 27, 2022
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Colon cancer is one of the most common types of cancer. Particularly in advanced stages of disease, the treatment still largely relies on traditional chemotherapy. The new generation of cancer treatments, so-called immunotherapies, ...
Mar 31, 2022
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Irish and German scientists have just identified how specific immune cells can work together in fat to cause inflammation that leads to weight gain and obesity. Their work pinpoints new avenues to exploit the regulation of ...
Mar 9, 2022
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A combination of two drugs that open the floodgates to an immune system attack on cancer curtailed tumor growth in some patients with non-small cell lung cancer (NSCLC) that was resistant to a single immunotherapy agent, ...
Jan 17, 2022
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A combination of two drugs that target different proteins on immune system T cells kept advanced melanoma in check significantly longer than one of the drugs alone in a phase 3 clinical trial involving 714 patients. Dana-Farber ...
May 20, 2021
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Cancer drugs called immune checkpoint inhibitors boost the immune system's ability to find and destroy tumor cells, but they don't work for most patients. Researchers at the Broad Institute of MIT and Harvard, Massachusetts ...
May 6, 2021
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