Medical research

Coupling antibiotics with stem cells to fight off bone infections

Bone infections caused by implants are difficult to treat and usually require a prolonged course of antibiotic treatment. In a new study, researchers from Kanazawa University discovered that implant-related bone infections ...

Surgery

The dark side of antibiotic ciprofloxacin

The use of ciprofloxacin and other antibiotics of the class of fluoroquinolones may be associated with disruption of the normal functions of connective tissue, including tendon rupture, tendonitis and retinal detachment. ...

Diseases, Conditions, Syndromes

Scientists develop test to identify best treatment for gonorrhea

Researchers from UCLA have developed a laboratory test that helps physicians determine which people with gonorrhea may be more treatable with an antibiotic that has not been recommended since 2007 because of concerns that ...

Surgery

Ciprofloxacin plus fluocinolone more effective for peds AOMT

(HealthDay)—For children with acute otitis media with tympanostomy tubes (AOMT), ciprofloxacin plus fluocinolone is more effective than ciprofloxacin or fluocinolone alone, according to a study published online Dec. 22 ...

Diseases, Conditions, Syndromes

Finafloxacin for the treatment of urinary tract infections

Results from a double-blind phase 2 clinical study show that finafloxacin was a more effective and safe option than ciprofloxacin for the treatment of complicated urinary tract infections and acute pyelonephritis. This research ...

Diseases, Conditions, Syndromes

Relative proportion of MRSA increasing in S. aureus isolates

(HealthDay)—The relative proportion of methicillin-resistant Staphylococcus aureus (MRSA) is increasing in S. aureus isolates, and methicillin-sensitive S. aureus (MSSA) is becoming increasingly resistant to antibiotics, ...

Diseases, Conditions, Syndromes

Antimicrobial resistance up in K. pneumoniae isolates

(HealthDay)—Klebsiella pneumoniae (K. pneumoniae) isolates from U.S. inpatients are becoming increasingly resistant to antimicrobial agents, according to a study published in the January issue of Emerging Infectious Diseases.

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Ciprofloxacin

Ciprofloxacin (INN) is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. It is a second-generation fluoroquinolone antibacterial. It kills bacteria by interfering with the enzymes that cause DNA to rewind after being copied, which stops synthesis of DNA and of protein.

Ciprofloxacin was first patented in 1983 by Bayer A.G. and subsequently approved by the U.S. Food and Drug Administration (FDA) in 1987. Ciprofloxacin has 12 FDA-approved human uses and other veterinary uses, but it is often used for unapproved uses (off-label). Ciprofloxacin interacts with other drugs, herbal and natural supplements, and thyroid medications.

As of 2011 the FDA has added two black box warnings for this drug in reference to spontaneous tendon ruptures and the fact that ciprofloxacin may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Such an adverse reaction is a potentially life-threatening event and may require ventilatory support.

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