Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. ...
Apr 11, 2023
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Results from the NRG Oncology Phase II NRG-GOG-0279 clinical study indicate that women with locally advanced squamous cell carcinoma of the vulva who received gemcitabine concurrently with cisplatin and intensity-modulated ...
Mar 27, 2023
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Adding nab-paclitaxel to a standard treatment of gemcitabine plus cisplatin does not significantly extend median overall survival (OS) time for patients with advanced biliary tract cancers, although it may provide a benefit ...
Jan 20, 2023
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Cisplatin is a chemotherapy indicated to fight tumors in many types of cancer. However, it does have major side effects—especially kidney toxicity, that can lead to acute kidney failure.
Nov 15, 2022
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An international team led by the Department of Neurosurgery, Niigata University, has identified a new gene called Schlafen11 (SLFN11) whose expression is tightly correlated with the response to chemotherapy in medulloblastomas, ...
Nov 8, 2022
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Extra copies of a piece of DNA partly explain insensitivity to chemotherapy in germ cell cancer, a new study shows. According to research leader Prof. Dr. Leendert Looijenga, "In the future, our findings could help pick out ...
Apr 20, 2022
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Modern medicine offers "peel and stick" solutions like nicotine or contraceptive patches that you can put right on your skin without needing to visit a doctor for an injection or procedure. Now, researchers have found that ...
Mar 30, 2022
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A new study suggests that the malaria drug hydroxychloroquine inhibits pathways that drive resistance to the chemotherapy agent cisplatin in head and neck cancers and restores tumor-killing effects of cisplatin in animal ...
Mar 14, 2022
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In a new paper accepted for publication in the Journal of the American Society of Nephrology, researchers at Yale School of Medicine share findings that indicate that, for the first time, there is a potential renal targeted ...
Dec 7, 2021
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The cancer drug cisplatin can save children's lives, but often with the side effect of hearing loss. Now a new study shows that young children are especially vulnerable, and the hearing damage may begin early in the course ...
Sep 28, 2021
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