Diseases, Conditions, Syndromes

Africa CDC sees COVID-19 vaccinations in 2nd quarter of 2021

Vaccinations against COVID-19 in Africa might not start until the second quarter of next year, the continent's top public health official said Thursday, adding that it will be "extremely dangerous" if more developed parts ...

Genetics

The genetics of side-effects

Henk-Jan Guchelaar knows all too well the serious problems that the side-effects of medication can cause. As a professor of clinical pharmacy at the University of Leiden in the Netherlands, he has spent the last two decades ...

Health

Iron infusion proves effective to treat anemia in rural Africa

Over 1 billion people globally are affected by iron-deficiency anemia. In sub-Saharan Africa, anemia is a major public health concern with roughly 60% of the population suffering from anemia. Around half of those cases are ...

Oncology & Cancer

Five steps to improve access to cancer immunotherapies

Most people are pretty familiar with the idea that our immune system can fight off invading bacteria and viruses, but the notion of it being effective against cancer is rather newer.

Vaccination

EU announces latest vaccine contract with Moderna

The EU said Tuesday it would sign a sixth contract for an upcoming coronavirus vaccine, this time for up to 160 million doses of a jab developed by US firm Moderna.

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Clinical trial

In clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. These trials can only take place once satisfactory information has been gathered on the quality of the product and its non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.

Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.

Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be the pharmaceutical or biotechnology company that developed the agent under study. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization

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