Researchers at Brigham and Women's Hospital have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system's ability to fight cancer.
Jun 14, 2024
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The European Alliance of Associations for Rheumatology has long recognized the pivotal role of patients in the development of recommendations, and the role of patients in research is also evolving. But collaboration with ...
Jun 14, 2024
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In an animal model of Duchenne muscular dystrophy, Brazilian researchers tested a therapy that combines photobiomodulation using laser light or light-emitting diodes (LEDs) with idebenone, an antioxidant compound investigated ...
Jun 14, 2024
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Periods of fasting reprogram the immune system's natural killer cells to better fight cancer, according to a new study in mice from researchers at Memorial Sloan Kettering Cancer Center (MSK).
Jun 14, 2024
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Though rare, medulloblastoma is the most common cancerous brain tumor in children. These tumors begin in the lower back part of the brain called the cerebellum, which is important for balance, coordination and movement. Medulloblastomas ...
Jun 14, 2024
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An analysis of reviews of translational biomedical research reveals that just 5% of therapies tested in animals reach regulatory approval for human use. The study, an umbrella review, published June 13 in the open access ...
Jun 13, 2024
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Changing the way antibiotics are given to adult patients with sepsis will save thousands of lives a year globally, according to research by The University of Queensland and The George Institute for Global Health.
Jun 13, 2024
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A viral gene therapy developed by University at Buffalo researchers has reversed some brain abnormalities in infant mice with FOXG1 syndrome, a significant step toward one day treating children with this severe neurodevelopmental ...
Jun 13, 2024
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Herbal medicines have been an integral part of traditional health care systems worldwide, dating back thousands of years. These natural remedies, rooted in cultural traditions, are now experiencing a resurgence in popularity ...
Jun 12, 2024
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Scientists at the University of Southern California have developed an artificial intelligence (AI)-powered system to track tiny devices that monitor markers of disease in the gut. Devices using the novel system may help at-risk ...
Jun 12, 2024
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In clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. These trials can only take place once satisfactory information has been gathered on the quality of the product and its non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.
Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.
Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be the pharmaceutical or biotechnology company that developed the agent under study. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization
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