Immunology

Common denominator that triggers asthma in favorable environments

In recent decades, asthma has become a major public health problem. The exponential increase in asthma cases in industrialized countries over the past 50 years is due to major changes in the environment. Among these environmental ...

Medical research

Patients' avatars being used to test cystic fibrosis drugs

UNSW researchers are leading a revolutionary approach to managing treatment of cystic fibrosis using patients' derived lung and gut mini-organs or avatars to test how they will respond to the latest drugs.

Medical research

In cystic fibrosis, lungs feed deadly bacteria

In cystic fibrosis, Pseudomonas aeruginosa is a much-feared pathogen. The bacterium easily colonizes the lungs of people with cystic fibrosis, leading to chronic infections that are almost impossible to eradicate and are ...

Diseases, Conditions, Syndromes

Ivacaftor may reduce common infections in patients with CF

Patients with cystic fibrosis who take ivacaftor appear to have fewer respiratory infections over time than those not taking the drug, according to new research published online in the Annals of the American Thoracic Society.

Diseases, Conditions, Syndromes

CFTR inhibition: The key to treating bile acid diarrhea?

Estimates are that roughly 1 percent of people in Western countries may have bile acid diarrhea, including patients with Crohn's disease, ileal resection, diarrhea-predominant irritable bowel syndrome (IBS-D), and chronic ...

Diseases, Conditions, Syndromes

Adding clinical variables improves accuracy of lung allocation score

Implemented back in 2005, the lung allocation score is used to prioritize patients awaiting lung transplants in the United States. Sicker transplant candidates have a higher calculated score and are placed at the top of the ...

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