Inflammatory proteins, also known as cytokines, play a crucial role in the immune response. If this immune response is too strong, a phenomenon known as "cytokine storm," it can cause harm to the patient. It has been thought ...
Sep 4, 2020
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As countries around the world race to develop a vaccine for SARS-CoV-2, the virus responsible for COVID-19, researchers are working to understand exactly how it causes the myriad of symptoms that seem to linger long after ...
Aug 31, 2020
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Mount Sinai scientists have identified two markers of inflammation that reliably predict the severity of COVID-19 cases and likelihood of survival, providing a foundation for a diagnostic platform and therapeutic targets, ...
Aug 24, 2020
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The severity of COVID-19 can vary hugely. In some it causes no symptoms at all and in others it's life threatening, with some people particularly vulnerable to its very severe impacts.
Aug 24, 2020
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The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19. When large numbers of immune cells release cytokines, this increases inflammation and creates a feedback ...
Aug 19, 2020
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In the early days of the COVID-19 pandemic, the SARS-CoV-2 virus seemed only rarely to have serious complications in children. However, by April 2020, pediatricians had begun recognizing a syndrome in children who tested ...
Jul 31, 2020
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Pro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopolysaccharide (LPS) are known to activate NF-kB. NF-kB is a master regulator of inflammation and induces pro-inflammatory cytokines. Although ...
Jul 16, 2020
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Chimeric antigen receptor T-cell therapy (CAR T) has proved to be a valuable treatment option for patients with lymphoma who have failed other therapies. In clinical trials, the cellular immunotherapy was shown to provide ...
Jul 15, 2020
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It's a trajectory followed by many who experience a severe case of COVID-19: They feel poorly for a few days, improve over a day or two and then, a week or 10 days into their infection, have respiratory difficulties, a stroke, ...
Jul 8, 2020
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Doctors can examine COVID-19 patients' blood to identify those at greatest risk of severe illness and to pinpoint those most likely to need a ventilator, new research from the University of Virginia School of Medicine suggests.
Jun 30, 2020
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