A high-risk subtype of acute lymphoblastic leukemia (ALL) first identified in children is highly prevalent in adults with ALL and is associated with a poor outcome, according to an international collaboration led by St. Jude ...
Nov 21, 2016
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During pregnancy, a woman's immune system changes dramatically but researchers don't yet understand all the underlying mechanisms. A new study shows how the gut microbiota may play a role.
Feb 7, 2024
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A new study describes the mechanistic relationship between the cytokine interleukin-1ß, (IL-1ß) and obesity, showing that when IL-1ß levels are increased in obesity, IL-1 receptor signaling activates multiple pathways ...
Oct 18, 2018
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Chimeric antigen receptor T-cell therapy (CAR T) has proved to be a valuable treatment option for patients with lymphoma who have failed other therapies. In clinical trials, the cellular immunotherapy was shown to provide ...
Jul 15, 2020
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Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional ...
Feb 6, 2013
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Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have led a study published in PLoS One showing that the inhibition of a family member of NADPH oxidase enzyme, NOX4, plays an important role in liver fibrosis.
Nov 5, 2012
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A research team led by the National Institute for Physiological Sciences and joined by Hokkaido University explored the role of pain neurons in the regulation of endotoxic death. They found that peptide named Reg3γ acts ...
Mar 8, 2022
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Pro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopolysaccharide (LPS) are known to activate NF-kB. NF-kB is a master regulator of inflammation and induces pro-inflammatory cytokines. Although ...
Jul 16, 2020
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Researchers at the Paris Cardiovascular Research Center (PARCC) have shown how adhesion of Neisseria (N.) meningitidis to human microvessels in a humanized mouse model leads to the characteristic cutaneous lesions of meningococcal ...
Jan 24, 2013
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Some cytokines can enhance the production of aberrantly O-glycosylated IgA1, the main autoantigen in IgA nephropathy. The mechanism behind this observation is described in the Journal of Interferon & Cytokine Research (JICR).
Jul 19, 2022
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