(HealthDay) -- A class of heart medications, cardiac glycosides, can induce immunogenic cell death (ICD), whereby dying cancer cells are converted into a vaccine that stimulates antitumor response, according to a study published ...
Jul 23, 2012
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(Medical Xpress) -- New research from Karolinska Institutet shows that the survival for patients with chronic myeloproliferative diseases has improved in recent decades. This is despite the fact that no targeted drugs have ...
Jul 17, 2012
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The immune system produces diverse varieties of T cells (Fig. 1), such as pathogen-destroying cytotoxic T cells and immune response-boosting helper T cells. Regulatory T (Treg) cells restrain these other cells and prevent ...
Jul 6, 2012
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A new study from SUNY Downstate Medical Center in Brooklyn, New York, shows that MAL3-101, a recently developed inhibitor of the heat shock protein 70 (Hsp70), appears to have potent anti-tumor effects on multiple myeloma, ...
Jan 9, 2012
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The standard treatment for patients with advanced non-small cell lung cancer (NSCLC) is a combination of two old-fashioned cytotoxic chemotherapy drugs. The combination, however, comes with substantial toxicity. Now, Fox ...
Jun 1, 2011
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As part of the body’s front-line defences against infection, white blood cells called macrophages often infiltrate tumours in great numbers. However, according to new research published in the scientific journal Cancer ...
Apr 27, 2011
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Often undetected until it has progressed to an advanced stage, pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. The K-Ras mutant pancreatic cancer is one of the most common types. At present, there are no effective ...
Jun 6, 2022
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Dihydroartemisinin (DHA), an active metabolite of artemisinin and the most potent anti-malaria drug, is also used to treat autoimmune diseases such as systemic lupus erythematosus (SLE) and psoriasis. Since the first report ...
Mar 28, 2022
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Continuing PLOS Medicine's special issue on cancer genomics, Christos Hatzis of Yale University, New Haven, CT, USA and colleagues describe a new subtype of triple negative breast cancer that may be more amenable to treatment ...
Dec 13, 2016
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A limitation of organ transplant is acute rejection of the graft by the host immune system. Graft rejection is mediated by the development of CD8+ cytotoxic T cells that target donor MHC class I molecules, and in animal models, ...
Jan 21, 2016
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