A limitation of organ transplant is acute rejection of the graft by the host immune system. Graft rejection is mediated by the development of CD8+ cytotoxic T cells that target donor MHC class I molecules, and in animal models, ...
Jan 21, 2016
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For more than a decade, oncologists using cytotoxic chemotherapy to treat patients with advanced metastatic castration-resistant prostate cancer (mCRPC) have relied on the sequential use of single agent taxanes such as docetaxel ...
May 31, 2015
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A dramatic video has captured the behaviour of cytotoxic T cells - the body's 'serial killers' - as they hunt down and eliminate cancer cells before moving on to their next target.
May 19, 2015
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Decades' worth of textbook precepts about how our immune systems manage to avoid attacking our own tissues may be wrong.
May 19, 2015
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Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies.
Apr 16, 2015
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In recent years, a standard follow-up to colorectal cancer surgery has been to analyze the tumor tissue for the presence of immune cells. Finding high quantities of cytotoxic T cells, or "killer cells", means that there is ...
Feb 2, 2015
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Scientists from the Institute for Biomedical Research (IRB Barcelona) have carried out successful in vitro tests using wasp venom to kill tumour cells. The next step will be to test its efficacy in mouse models.
Aug 5, 2014
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A study which will be published in the May 2014 issue of Experimental Biology and Medicine was aimed at determining whether an EGFR-targeted therapy combined with chemo-radiotherapy can improve local tumor control effectively, ...
May 13, 2014
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Most cancer vaccines have not lived up to their promise in clinical trials. The reason, many researchers suspect, is that the immune cells that would help the body destroy the tumor – even those reactions boosted by cancer ...
Apr 28, 2014
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Adjuvant chemotherapy for breast cancer is "gerontogenic", accelerating the pace of physiologic aging, according to a new study published March 28 in the Journal of the National Cancer Institute.
Mar 28, 2014
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