When metastatic tumors driven by drug-targetable genetic mutations become resistant to a targeted therapy drug, the usual practice is to biopsy a single metastatic lesion to test for new mutations that can guide the selection ...
Feb 5, 2016
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A new technique for pinpointing the exact DNA regions that impact gene regulation lays the groundwork for identifying new drug targets and for developing diagnostics to predict disease risk, A*STAR scientists report.
Jan 6, 2016
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Our cells are up against a daily onslaught of damage to the DNA that encodes our genes. It takes constant effort to keep up with the DNA disrepair – and if our cells didn't bother to try to fix it, we might not survive. ...
Oct 9, 2015
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Understanding how our cells repair damaged DNA, a breakthrough which earned the Nobel Chemistry Prize on Wednesday, could make cancer treatment more effective, experts say.
Oct 7, 2015
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Working with tissue, blood and DNA from six people with precancerous and cancerous lung lesions, a team of Johns Hopkins scientists has identified what it believes are among the very earliest "premalignant" genetic changes ...
Sep 21, 2015
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Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
Sep 17, 2015
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Evolutionary theory says mutations are blind and occur randomly. But in the phenomenon of adaptive mutation, cells can peek under the blindfold, increasing their mutation rate in response to stress.
Aug 25, 2015
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Chronic inflammation caused by disease or exposure to dangerous chemicals has long been linked to cancer, but exactly how this process takes place has remained unclear.
Aug 7, 2015
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A new computational study published in the International Journal of Bioinformatics Research and Applications has shown how mutations that give rise to drug resistance occur in a form of cancer known as acute myeloid leukemia ...
Aug 4, 2015
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Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are ...
Aug 3, 2015
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