The pattern of genomic alterations in colon and rectal tissues is the same regardless of anatomic location or origin within the colon or the rectum, leading researchers to conclude that these two cancer types can be grouped ...
Jul 18, 2012
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Through a global gene expression analysis (transcriptomic), the researchers were able to find and confirm a genetic signature common to genodermatoses in patients' cells. The profile targets cellular activation and alteration ...
Mar 5, 2019
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Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts.
Feb 23, 2018
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When cancer cells divide they often make mistakes which can alter their DNA. While this can give cancer cells an upper hand, it can also be their downfall.
Mar 17, 2017
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Our DNA, which stores our genetic information, is constantly exposed to damage. If not properly repaired, DNA damage can lead to cell death. This, in turn, can lead to tissue exhaustion and ageing, or induce mutations resulting ...
Jan 3, 2013
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Scientists led by a group of researchers at The Scripps Research Institute (TSRI) in La Jolla, CA, have discovered some of the key proteins involved in one type of DNA repair gone awry.
May 22, 2014
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Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece ...
Mar 21, 2024
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An international research consortium led by the Universitat Autònoma de Barcelona (UAB), the CIBERER and the University of Wurzburg (Germany) has discovered a gene that can cause three totally different diseases, depending ...
Apr 25, 2013
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A new research paper titled "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes" has been published in Aging.
Dec 19, 2023
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DNA damage can lead to gene inactivation or deregulation and cause various diseases such as cancer; however, many DNA repair mechanisms allow cells to survive against such damage. A study lead by Antoine Simoneau of the laboratory ...
Jan 28, 2016
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