News tagged with dopamine

Related topics: brain · parkinson s disease · brain cells · attention deficit hyperactivity disorder · biological psychiatry

Realistic rodent model of drug addiction

Drug addiction may not require a habitual relationship with a substance, suggests findings from a new model of cocaine administration in rats that better captures the human experience of obtaining and using drugs. The research, ...

Nov 20, 2017
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A new target for marijuana

Cellular-level changes to a part of the brain's reward system induced by chronic exposure to the psychoactive component of marijuana may contribute to the drug's pleasurable and potentially addictive qualities, suggests a ...

Oct 16, 2017
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Dopamine

Dopamine is a neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4, and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary.

Dopamine can be supplied as a medication that acts on the sympathetic nervous system, producing effects such as increased heart rate and blood pressure. However, because dopamine cannot cross the blood-brain barrier, dopamine given as a drug does not directly affect the central nervous system. To increase the amount of dopamine in the brains of patients with diseases such as Parkinson's disease and dopa-responsive dystonia, L-DOPA (levodopa), which is the precursor of dopamine, can be given because it can cross the blood-brain barrier.

This text uses material from Wikipedia, licensed under CC BY-SA

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