Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and muscles, and are an ...
Sep 13, 2021
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Researchers at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and collaborators from the School of Basic Medical Sciences, Fudan University, Shanghai, have developed an 'intravenous injection plus light-triggered ...
Aug 30, 2021
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Drug delivery plays an important role in the treatment of diseases. Matching a specific drug molecule with the right delivery route optimizes therapeutic performance and minimizes side effects. Associate Professor Matthias ...
Aug 19, 2021
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Researchers from Tokyo Medical and Dental University (TMDU), Takeda Pharmaceutical Co., Ltd. and Ionis Pharmaceuticals, USA, show that heteroduplex oligonucleotide drugs conjugated with cholesterol cross the blood–brain ...
Aug 12, 2021
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288
In a major advancement in the field of gene therapy for rare and devastating diseases, researchers at Children's Hospital of Philadelphia (CHOP) have developed a "dimmer switch" system that can control levels of proteins ...
Jul 28, 2021
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It can be difficult to get drugs to disease sites along the gastrointestinal tract, which spans the mouth, esophagus, stomach, small and large intestine, and anus. Invasive treatments can take hours as patients wait for adequate ...
Jul 20, 2021
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Sclerosis, Parkinson's disease, Alzheimer's and epilepsy are central nervous system disorders. They are also very difficult to treat, since the brain is protected by the blood-brain barrier.
Jul 12, 2021
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Researchers in a Horizon 2020 project called EDEN2020 have proven what they set out to do over 5 years ago: directionality of needle insertion plays a crucial role when infusing drugs into the brain.
Jun 22, 2021
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Inspired by kirigami, the Japanese art of folding and cutting paper to create three-dimensional structures, MIT engineers and their collaborators have designed a new type of stent that could be used to deliver drugs to the ...
Jun 14, 2021
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Treatment for fungal lung infections could be more efficient when medication is inhaled using nanoparticle technology, according to research from the University of Central Lancashire (UCLan).
May 21, 2021
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